SrasV1, Main, Exploration, bibRecord, 004262

Human Immunosenescence

Identifieur interne : 004262 ( Main/Exploration ); précédent : 004261; suivant : 004263

Human Immunosenescence

Auteurs : G. Pawelec [Allemagne] ; S. Koch [Allemagne] ; C. Franceschi [Italie] ; A. Wikby [Suède]

Source :

Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2006-05.

RBID : ISTEX:E3E5309A579A002A77ED8ECFFD70C8F6D021FD2A

Descripteurs français

KwdFr :
- Animaux, Cytomegalovirus (immunologie), Cytomegalovirus (pathogénicité), Humains, Immunité (immunologie), Infections à cytomégalovirus (immunologie), Infections à cytomégalovirus (virologie), Lymphocytes T CD8+ (immunologie), Modèles immunologiques, Sujet âgé, Vieillissement (immunologie), Études longitudinales.
MESH :
- immunologie : Cytomegalovirus, Immunité, Infections à cytomégalovirus, Lymphocytes T CD8+, Vieillissement.
- pathogénicité : Cytomegalovirus.
- virologie : Infections à cytomégalovirus.
- Animaux, Humains, Modèles immunologiques, Sujet âgé, Études longitudinales.

English descriptors

KwdEn :
- Aged, Aging (immunology), Animals, CD8-Positive T-Lymphocytes (immunology), Cytomegalovirus (immunology), Cytomegalovirus (pathogenicity), Cytomegalovirus Infections (immunology), Cytomegalovirus Infections (virology), Humans, Immunity (immunology), Longitudinal Studies, Models, Immunological.
MESH :
- immunology : Aging, CD8-Positive T-Lymphocytes, Cytomegalovirus, Cytomegalovirus Infections, Immunity.
- pathogenicity : Cytomegalovirus.
- virology : Cytomegalovirus Infections.
- Aged, Animals, Humans, Longitudinal Studies, Models, Immunological.

Abstract

Abstract: The rate of acceleration of the frequency of death due to cardiovascular disease or cancer increases with age from middle age up to around 75–80 years, plateauing thereafter. Mortality due to infectious disease, however, does not plateau, but continues to accelerate indefinitely. The elderly are particularly susceptible to novel infectious agents such as SARS, as well as to previously encountered pathogens. Why is this? The elderly commonly possess oligoclonal expansions of T cells, especially of CD8 cells, which, surprisingly, are associated with cytomegalovirus (CMV) seropositivity. This in turn is associated with many of the same phenotypic and functional alterations to T cell immunity that have been suggested as biomarkers of immune system aging. We suggest that, in fact, CMV, not age per se, is the prime driving force behind many or most of the oligoclonal expansions and altered phenotypes and functions of CD8 cells in the elderly. Thus, the manner in which CMV and the host immune system interact (over which period? on which genetic background? with which co‐infections?) is critical in determining the “age” of adaptive immunity and hence human longevity. In this respect, immunosenescence is infectious.

Url:

https://api.istex.fr/ark:/67375/WNG-FQXVB8NN-5/fulltext.pdf

DOI: 10.1196/annals.1354.009

Affiliations:

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<front><div type="abstract" xml:lang="en">Abstract:  The rate of acceleration of the frequency of death due to cardiovascular disease or cancer increases with age from middle age up to around 75–80 years, plateauing thereafter. Mortality due to infectious disease, however, does not plateau, but continues to accelerate indefinitely. The elderly are particularly susceptible to novel infectious agents such as SARS, as well as to previously encountered pathogens. Why is this? The elderly commonly possess oligoclonal expansions of T cells, especially of CD8 cells, which, surprisingly, are associated with cytomegalovirus (CMV) seropositivity. This in turn is associated with many of the same phenotypic and functional alterations to T cell immunity that have been suggested as biomarkers of immune system aging. We suggest that, in fact, CMV, not age per se, is the prime driving force behind many or most of the oligoclonal expansions and altered phenotypes and functions of CD8 cells in the elderly. Thus, the manner in which CMV and the host immune system interact (over which period? on which genetic background? with which co‐infections?) is critical in determining the “age” of adaptive immunity and hence human longevity. In this respect, immunosenescence is infectious.</div>
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Human Immunosenescence

Human Immunosenescence

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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